Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators

Glucocorticoid receptor (GR) is a ligand-dependent transcription issue that performs a central position in irritation. GR exercise can also be modulated by way of protein-protein interactions, together with binding of 14-3-Three proteins induced by GR phosphorylation. However, the particular phosphorylation…

Expression of yhwaz and gene regulation network in hepatocellular carcinoma.

Expression of yhwaz and gene regulation network in hepatocellular carcinoma.

The adaptor protein 14-3-3ζ is encoded by the yhwaz gene and implicated in a variety of organic processes. In tumorigenesis, 14-3-3ζ acknowledges particular phosphorylation motifs and interacts with a whole lot of goal proteins and is, thus, concerned in the regulation of tumor proliferation, migration and differentiation. In…