Pancreatic cancer (PC) is one of the most well-known malignancies with high mortality, but the underlying mechanism of PC remains unknown. Keratin17 (KRT17) expression has been reported in many malignancies, but its functions in PC are not clear. The aim of our study was to evaluate KRT17 expression and its potential role in PC.
The online databases GEPIA and THPA were used to identify KRT17 expression in tissues. Quantitative real-time PCR (qRT-PCR) was used to determine KRT17 expression in cell lines. Ki67 and ROS levels were detected by immunofluorescence assay and a 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) probe. KRT17 downregulation was induced by the small interfering RNA (siRNA) technique.
Proliferation function was evaluated by colony formation assay and RTCA. Migration and invasion were evaluated by transwell migration assay. A Western blot assay was used to detect protein levels.KRT17 was overexpressed in PC tissues compared to that in normal tissues. The results showed that Ki67 and ROS levels were decreased in pancreatic cancer cells after transfection with siKRT17.
 Individual Reaction Mix 3 |
|
G065-3 |
ABM |
200 reactions |
EUR 167 |
 3-D Life Thioglycerol |
|
T10-3 |
Cellendes |
180 µl |
EUR 48 |
 Western Blot Box - 2 7/8 x 1 3/16 x 3/4in.; 7.3 x 3 x 1.9cm |
|
B1200-3 |
MTC Bio |
5/pack |
EUR 63.77 |
|
Description: Western Blot Boxes |
 TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant |
|
PROTP10600-3 |
BosterBio |
Regular: 5ug |
EUR 317 |
|
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques. |
 Dr. P Kit-Solution 3 |
|
K2021010-3 |
Biochain |
50 ml |
EUR 133 |
|
Description: Can be used for various proteomics studies in both normal and pathological cases. It is an excellent control and suitable for educational purposes. This product is prepared from whole tissue homogenates and has undergone SDS-PAGE quality control analysis. The protein is stored in a buffer with protease inhibitor cocktail fo prevent degradation. |
 3-D Life PEG-Link |
|
L50-3 |
Cellendes |
3x 200 µl |
EUR 94 |
 3-D Life CD-Link |
|
L60-3 |
Cellendes |
3 x 200 µl |
EUR 321 |
 3-D-Life SG-PVA |
|
M81-3 |
Cellendes |
3x 170 µl |
EUR 148 |
 3-D Life FG-PVA |
|
M82-3 |
Cellendes |
3x 170 µl |
EUR 148 |
 3-D Life SG-Dextran |
|
M91-3 |
Cellendes |
3x 170 µl |
EUR 157 |
 3-D Life FG-Dextran |
|
M92-3 |
Cellendes |
3x 170 µl |
EUR 157 |
 3-D Life RGD Peptide |
|
P10-3 |
Cellendes |
3x 1 µmol |
EUR 276 |
 Recombinant Human MMP-3 Protein |
|
PROTP08254-3 |
BosterBio |
10ug |
EUR 317 |
|
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids). |
 Caspase-3 Inhibitor Q-DEVD-OPh |
|
1175-3 |
Biovision |
|
EUR 533 |
 Anti-VEGF Receptor 3/FLT4 Antibody |
|
A01276-3 |
BosterBio |
100ug/vial |
EUR 334 |
 3-D Life Scrambled RGD Peptide |
|
P11-3 |
Cellendes |
3x 1 µmol |
EUR 276 |
 ELISA test) FSH (Human Follicle-stimulating hormone) ELISA test |
|
3 |
Biobase |
96T/Box |
Ask for price |
- Area of application: Hormone testing
|
|
Description: ELISA based test for quantitative detection of FSH (Human Follicle-stimulating hormone) |
 Anti-active Caspase-3 Rabbit Monoclonal Antibody |
|
M00334-3 |
BosterBio |
100ug/vial |
EUR 397 |
|
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human |
) Anti-Galectin 3/LGALS3 Antibody (monoclonal, 12B12) |
|
M00621-3 |
BosterBio |
100ug/vial |
EUR 334 |
) QuantiMir 3'-Universal Primer (10,000 qPCR reactions) |
|
RA420AU-3 |
SBI |
10,000 assays |
EUR 178 |
|
|
) SeraMir 3'-Universal Primer (10,000 qPCR reactions) |
|
RA800P-3 |
SBI |
10,000 reactions |
EUR 178 |
|
|
 Caspase-3 DEVD-R110 Fluorometric HTS Assay Kit |
|
30009-3 |
Biotium |
1KIT |
EUR 809 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
) 3-D Life 10x CB Buffer (pH 7.2) |
|
B20-3 |
Cellendes |
600 µL |
EUR 44 |
) 3-D Life 10x CB-Buffer (pH 5.5) |
|
B10-3 |
Cellendes |
600 µl |
EUR 44 |
 Anti-Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Monoclonal Antibody |
|
M00227-3 |
BosterBio |
100ul |
EUR 397 |
|
Description: Mouse Monoclonal Glyceraldehyde 3-Phosphate Dehydrogenase [GAPDH] Antibody. Validated in IHC, WB and tested in Equine. |
 PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9 |
|
PROTP49763-3 |
BosterBio |
Regular: 25ug |
EUR 317 |
|
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques. |
) ExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions) |
|
M1030-3 |
Biovision |
|
EUR 441 |
) ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, cell media, 3 reactions) |
|
M1031-3 |
Biovision |
|
EUR 436 |
) TumorExoPure? 0.4 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions) |
|
M1032-3 |
Biovision |
|
EUR 436 |
) TumorExoPure? 1.0 micron Immunobeads (Tumor-derived Exosome Isolation, biofluids, 3 reactions) |
|
M1033-3 |
Biovision |
|
EUR 436 |
) MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions) |
|
M1034-3 |
Biovision |
|
EUR 332 |
) MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse biofluids, 3 reactions) |
|
M1035-3 |
Biovision |
|
EUR 430 |
) MouseExoPure? 0.4 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions) |
|
M1036-3 |
Biovision |
|
EUR 430 |
) MouseExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, mouse cell media, 3 reactions) |
|
M1037-3 |
Biovision |
|
EUR 430 |
) ExoPure? 1.0 micron Immunobeads (Overall Exosome Isolation, plasma, urine, serum, 3 reactions) |
|
M1039-3 |
Biovision |
|
EUR 436 |
Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein) ANGPTL3 (17-460)Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein |
|
PROTQ9Y5C1-3 |
BosterBio |
Regular: 10ug |
EUR 317 |
|
Description: ANGPTL3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 453 amino acids (17-460 a.a.) and having a molecular mass of 52.9kDa (Migrates at 25-70kDa on SDS-PAGE under reducing conditions). |
) Lethal factor Protease Substrate 3, AMC derivative MEk2 peptide substrate for high-throughput screening of LF inhibitors (14aa) |
|
LFPS-3 |
Alpha Diagnostics |
1 mg |
EUR 408 |
 IgG (Clone #3)) Mouse Monoclonal anti-PEG (backbone specific) IgG (Clone #3) |
|
PEG13-M-3 |
Alpha Diagnostics |
100 ug |
EUR 482 |
) Mouse Monoclonal anti-Clostridium difficile toxin A IgG (Clone #3) |
|
CDTA12-M-3 |
Alpha Diagnostics |
100 ug |
EUR 482 |
 Sheep Gamma Globulin |
|
29005-3 |
Pel-Freez |
50g |
EUR 1876 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: This Sheep gamma globulin is purified from serum obtained from normal healthy animals (male and female) by using various fractionation procedures followed by dialysis against low ionic strength buffer. It is in lyophilized powder form with purity of 95% or more. Protein by weight: O.D. 280 nm E1%1.39: ? 85% - Residual salts, lipids, etc. comprise the rest of the weight. |
 Caspase-8 IETD-R110 Fluorometric HTS Assay Kit |
|
30012-3 |
Biotium |
1KIT |
EUR 1627 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
) Steady-Luc Firefly HTS Assay Kit (10x100 ml) |
|
30028-3 |
Biotium |
1KIT |
EUR 3145 |
|
Description: Minimum order quantity: 1 unit of 1KIT |
 Goat Gamma Globulin |
|
22005-3 |
Pel-Freez |
50g |
EUR 1205 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: Goat gamma globulin is purified from serum obtained from normal healthy animals (male and female) by using various fractionation procedures followed by dialysis against low ionic strength buffer. It is in lyophilized powder form with purity of 98% or more. Protein by weight: O.D. 280 nm E1%1.39: ? 85% - Residual salts, lipids, etc. comprise the rest of the
weight. |
) Rabbit Complement (21-28 days old rabbits) |
|
31061-3 |
Pel-Freez |
100mL |
EUR 1102 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: The complement is isolated from large pools of New Zealand White rabbits that are 21-28 days old and raised under strictly controlled conditions. This guarantees that the complement has low heterophile antibody activity for many applications, including use in bactericidal and opsonization assays. The complement is extremely heat-sensitive. Prior to working with it we recommend that the complement is thawed on ice or in a cold water bath or under a stream of cold water. Never thaw using warm or hot water. While defrosted like this we advise you to make single-use aliquots and keep them frozen at -70C. Freeze-thaw cycles will damage the complement components and will reduce significantly the activity. Once thawed, the leftover from a working aliquot should be discarded. |
 Rabbit Complement Adsorbed |
|
31063-3 |
Pel-Freez |
100mL |
EUR 246 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: The complement is collected from healthy 8-12 week old rabbits (both male and female) and stored at -70°C. It is in the form of frozen liquid. The Hemolytic titer is LOT dependant but generally above 1:16. The complement is extremely heat-sensitive. Prior to working with it we recommend that the complement is thawed on ice or in a cold water bath or under a stream of cold water. Never thaw using warm or hot water. While defrosted like this we advise you to make single-use aliquots and keep them frozen at -70C. Freeze-thaw cycles will damage the complement components and will reduce significantly the activity. Once thawed, the leftover from a working aliquot should be discarded. |
) Rabbit Serum, Non-Sterile, Non-Hemolyzed (56-84 days old) |
|
31118-3 |
Pel-Freez |
3L |
EUR 710 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: Produced from whole blood collected from young healthy rabbits (New Zealand White or Californian), 6+ months old. Pooled serum from male and female rabbits that are fasted prior to collection. The serum is processed, bottled, and stored at -20°C. |
) Rabbit Serum, Non-Sterile, Trace-Hemolyzed (56-84 days old) |
|
31119-3 |
Pel-Freez |
3L |
EUR 645 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: Produced from whole blood collected from young healthy rabbits (New Zealand White or Californian), 6+ months old. Pooled serum from male and female rabbits that are fasted prior to collection. The serum is processed, bottled, and stored at -20°C. |
) Rabbit Serum Sterile, trace-hemolized (56-84 days old) |
|
31126-3 |
Pel-Freez |
3L |
EUR 694 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: Produced from whole blood collected from young healthy rabbits (New Zealand White or Californian), 6+ months old. Pooled serum from male and female rabbits that are fasted prior to collection. The serum is processed, bottled, and stored at -20°C. Then the serum was thawed, pooled, passed through a 0.22-micron filter, bottled and returned to -20°C. |
 Anti-RAB3GAP2 Antibody |
|
A07244-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-FOXI1 Antibody |
|
A07512-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-IL36 alpha/IL36A Antibody |
|
A09802-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-IL17B Antibody |
|
A10846-3 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-RBMS3 Antibody |
|
A12416-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-Aldolase/ALDOA Antibody |
|
A05022-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-SENP6 Antibody |
|
A05088-3 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-ZNFN1A2/HELIOS/IKZF2 Antibody |
|
A05228-3 |
BosterBio |
100ug/vial |
EUR 294 |
 Bovine Serum Sterile, Non-Hemolyzed, Delipidized |
|
37146-3 |
Pel-Freez |
500mL |
EUR 198 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: Whole blood is collected from healthy animals of mixed breed both male and female that are 1+ years of age. The blood is refrigerated within 6 hours after collection and is processed within 24 hours and frozen at -20°C. The serum is then thawed in a cool water bath. First the lipids are removed, then the serum is filtered through a 0.22 micron filter. The obtained product is bottled and frozen at -20 ºC. |
 Horse Serum Non-Sterile, Non-Hemolyzed |
|
39321-3 |
Pel-Freez |
500mL |
EUR 129 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: Whole blood is collected from both male and female healthy horses living in a herd and are 1+ years of age. The blood is refrigerated within 6 hours after collection and is processed within 24 hours and frozen at -20°C. |
 Pig Serum, Non-Sterile, Trace-Hemolyzed |
|
39328-3 |
Pel-Freez |
3L |
EUR 356 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: Whole blood is collected from healthy pigs of mixed breed, either sex and fasted at the time of slaughter. The blood is then refrigerated within 6 hours, processed within 24 hours and frozen at -20°C. |
 QVD-OPh Negative Control |
|
1171-3 |
Biovision |
|
EUR 403 |
 Caspase-8 Inhibitor, Q-IETD-OPh |
|
1176-3 |
Biovision |
|
EUR 686 |
 Caspase-9 Inhibitor, Q-LEHD-OPh |
|
1177-3 |
Biovision |
|
EUR 675 |
 ACES™ YebF Protein Export Kit |
|
0148-3 |
AthenaES |
kit |
EUR 311 |
 Human recombinant UBE2D3 |
|
6430-3 |
Biovision |
|
EUR 365 |
 Human recombinant UBE2L3 |
|
6431-3 |
Biovision |
|
EUR 365 |
) Human recombinant UBE2R1 (CDC34) |
|
6436-3 |
Biovision |
|
EUR 365 |
) Human recombinant UBE2R2 (Ubc3B) |
|
6437-3 |
Biovision |
|
EUR 392 |
) Human recombinant UBE2E2 (UbcH8) |
|
6438-3 |
Biovision |
|
EUR 392 |
 Mouse anti-dsDNA IgG3-specific ELISA Kit, 96 tests, Quantitative |
|
5120-3 |
Alpha Diagnostics |
1 kit |
EUR 712 |
 *Ship from CRL) TARGATT? attp Mouse B6 (Age: 36-42 days) *Ship from CRL |
|
549-3 |
Applied StemCell |
1 female |
Ask for price |
|
Description: N/A |
Pig Serum, Non-Sterile, Trace-Hemolyzed |
|
39519-3 |
Pel-Freez |
500mL |
EUR 149 |
- All products from Pel-Freez are available in Europe and worldwide via Gentaur. If you cannot find the item you need send us an inquiry and we will be in touch with you with pricing and delivery information in less than 12 hours.
|
|
Description: Whole blood is collected from healthy pigs of mixed breed, either sex and fasted at the time of slaughter. The blood is then refrigerated within 6 hours, processed within 24 hours and frozen at -20°C. |
 ABC diluent buffer |
|
AR1106-3 |
BosterBio |
12ml |
EUR 91 |
 Genomic DNA from Congenital heart disease: Heart, from a single donor |
|
D1236122Hd-3 |
Biochain |
50 ug |
EUR 446 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Genomic DNA from Emphysema: Lung, from a single donor |
|
D1236152Ld-3 |
Biochain |
50 ug |
EUR 446 |
|
Description: Can be used for various studies in the realm of gene expression, both normal and pathological. It is an excellent control and suitable for educational purposes. |
 Antibody) Anti-Smad1 (Ab-465) Antibody |
|
A00728-3 |
BosterBio |
100ul |
EUR 397 |
|
Description: Rabbit Polyclonal Smad1 (Ab-465) Antibody. Validated in IF, WB and tested in Human, Mouse, Rat. |
 Anti-LOX 1/Olr1 Antibody |
|
A00760-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-Collagen III/COL3A1 Antibody |
|
A00788-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-LBP Antibody |
|
A00809-3 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-Fibrinogen alpha chain/FGA Antibody |
|
A00816-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-VEGF Receptor 2/Kdr Antibody |
|
A00901-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-Cystatin C/Cst3 Antibody |
|
A00961-3 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-IL22 Antibody |
|
A00963-3 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-uPA Receptor/PLAUR Antibody |
|
A00993-3 |
BosterBio |
100ug/vial |
EUR 334 |
 Anti-AMPK alpha 1/PRKAA1 Antibody |
|
A00994-3 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-MBL2 Antibody |
|
A01000-3 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-BCMA/Tnfrsf17 Antibody |
|
A01014-3 |
BosterBio |
100ug/vial |
EUR 294 |
 Anti-KCNH1 Antibody |
|
A01036-3 |
BosterBio |
100ug/vial |
EUR 294 |
After KRT17 downregulation in PC cell lines, cell viability functions, including proliferation, migration and invasion, and mTOR/S6K1 phosphorylation levels were attenuated.KRT17 knockdown significantly inhibited proliferation, migration and invasion in pancreatic cancer cells.
)
