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Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins

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Ras undergoes interconversion between the energetic GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the actions of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide trade elements (SOS). Oncogenic Ras mutations might have…