An in depth relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility, and protein tyrosine phosphatase 1B (PTP1B) could also be concerned in sustaining this homeostasis. The steady residence of mesenchymal stem cells (MSCs) and endothelial cells (ECs) of their niches is carefully associated to the regulation of PTP1B. However, the precise position of the departure of MSCs and ECs from their niches throughout bone regeneration is essentially unknown. Here, we present that the phosphorylation state of PTP1B tyrosine-152 (Y152) performs a central position in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.
Based on our earlier design of a PTP1B Y152 region-mimicking peptide (152RM) that considerably inhibits the phosphorylation of PTP1B Y152, additional investigations revealed that 152RM enhanced cell migration partly through integrin αvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3. Moreover, 152RM induced kind H vessels formation by activating Notch signaling. Demineralized bone matrix (DBM) scaffolds had been fabricated with mesoporous silica nanoparticles (MSNs), and 152RM was then loaded onto them by electrostatic adsorption. The DBM-MSN/152RM scaffolds had been demonstrated to induce bone formation and sort H vessels growth in vivo.
Elevated expression of β4-galactosyltransferase (β4GalT) Three is correlated with poor medical consequence of neuroblastoma sufferers. Our current examine has revealed that the transcription of the β4GalT3 gene is activated by Specificity protein (Sp) Three in SH-SY5Y human neuroblastoma cell line. Here we report the organic significance of the SpThree phosphorylation within the transcriptional activation of the β4GalT3 gene. The therapy of SH-SY5Y cells with 10% fetal bovine serum (FBS) elevated the mitogen-activated protein kinase (MAPK) signaling and the promoter exercise of the β4GalT3 gene.
Meanwhile, the therapy with U0126, an inhibitor for MAPK kinase, decreased the MAPK signaling and the promoter exercise. These findings point out that the transcriptional activation of the β4GalT3 gene is mediated by the MAPK signaling. In SH-SY5Y cells cultured within the medium containing 10% FBS, the serine (Ser) residues in SpThree had been phosphorylated. In conclusion, our knowledge reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis, which can provide a possible therapeutic technique for bone defects.
Quantitative Phosphoproteomics Reveals the Role of Protein Arginine Phosphorylation within the Bacterial Stress Response
Arginine phosphorylation is an rising protein modification implicated within the common stress response of Gram-positive micro organism. The modification is mediated by the arginine kinase McsB, which phosphorylates and inactivates the warmth shock repressor CtsR. In this examine, we developed a mass spectrometric method accounting for the peculiar chemical properties of phosphoarginine. The improved methodology was used to investigate the dynamic adjustments within the Bacillus subtilis arginine phosphoproteome in response to completely different stress conditions.
Quantitative evaluation confirmed {that a} B. subtilis mutant missing the YwlE arginine phosphatase accrued a strikingly massive quantity of arginine phosphorylations (217 websites in 134 proteins), nevertheless solely a minor fraction of these websites was more and more modified throughout warmth shock or oxidative stress. The most important targets of McsB-mediated arginine phosphorylation comprise central elements of the stress response system together with the CtsR and HrcA warmth shock repressors, in addition to main elements of the protein high quality management system such because the ClpCP protease and the GroEL chaperonine.
These findings spotlight the impression of arginine phosphorylation in orchestrating the bacterial stress response. In vegetation, SNF1-related protein kinase 1 (SnRK1) senses nutrient and power standing and transduces this info into applicable responses. Oxidative Stress 3 (OXS3) and members of the family share a extremely conserved putative N-acetyltransferase catalytic area (ACD). Here, we describe that the ACD comprises two candidate SnRK1 recognition motifs and that SnRK1 can work together with most of the OXS3 household proteins. In vitro, SnRK1.1 can phosphorylate OXS3, OXS3b and O3L4, and in vivo promote the translocation of OXS3, OXS3b and O3L6 from the nucleus to the cytoplasm.
Arg-Gly-Asp-modified elastin-like polypeptide regulates cell proliferation and cell cycle proteins through the phosphorylation of Erk and Akt in pancreatic β-cell
Enhancement of β-cell proliferation performs an vital position in sustaining β-cell mass and performance, and in enhancing pancreatic β-cell survival earlier than transplantation. Extracellular matrix (ECM) elements enhance the adhesion and proliferation of β-cells, and the RGD-modified elastin-like polypeptide (RGD-ELP, REP) has been described as a bioactive matrix. In this examine, we investigated whether or not REP may improve β-cell adhesion and proliferation and elucidated the signaling pathways concerned.
We investigated the impact of REP on cell adhesion, proliferation and insulin secretion through assays utilizing Rin-m and rat islets. Crystal violet, CCK-8, and BrdU assay, FACS, western blot, actual time q-PCR analyses and insulin ELISA had been examined. To clarify the related mechanisms, phosphorylation of Akt and extracellular signal-regulated kinase (Erk) had been measured.REP extra elevated the adhesion, proliferation and survival of Rin-m cells in comparison with elastin-like poly peptide (ELP) with out RGD-motif. The enhancement of β-cell proliferation by REP was related with elevated cyclin D1, cyclin D2 and cdk6, and decreased p27 ranges.
Capsid protein VP1 Antibody |
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| abx317823-50g | Abbexa | 50 µg | EUR 250 |
Rotavirus Capsid Protein Antibody |
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| GWB-598577 | GenWay Biotech | 0.1 mg | Ask for price |
Rotavirus Capsid Protein Antibody |
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| abx415701-01mg | Abbexa | 0.1 mg | EUR 526.8 |
Astrovirus Capsid Protein Antibody |
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| GWB-T00714 | GenWay Biotech | 1 mg | Ask for price |
Major capsid protein L1 antibody |
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| 70R-15488 | Fitzgerald | 100 ug | EUR 303 |
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Description: Rabbit polyclonal Major capsid protein L1 antibody |
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Capsid protein VP1 Antibody (HRP) |
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| 20-abx317824 | Abbexa |
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Capsid protein VP1 Antibody (HRP) |
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| abx317824-100g | Abbexa | 100 µg | EUR 362.5 |
Capsid protein VP1 Antibody (HRP) |
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| abx317824-20g | Abbexa | 20 µg | EUR 162.5 |
Capsid protein VP1 Antibody (HRP) |
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| abx317824-50g | Abbexa | 50 µg | EUR 250 |
Capsid protein VP1 Antibody (FITC) |
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| 20-abx317825 | Abbexa |
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Capsid protein VP1 Antibody (FITC) |
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| abx317825-100g | Abbexa | 100 µg | EUR 362.5 |
Capsid protein VP1 Antibody (FITC) |
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| abx317825-20g | Abbexa | 20 µg | EUR 162.5 |
Capsid protein VP1 Antibody (FITC) |
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| abx317825-50g | Abbexa | 50 µg | EUR 250 |
Norovirus GI Capsid Protein Antibody |
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| abx024099-1mg | Abbexa | 1 mg | EUR 1128 |
Norovirus GI Capsid Protein Antibody |
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| abx024100-1mg | Abbexa | 1 mg | EUR 1128 |
Norovirus GI Capsid Protein Antibody |
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| abx024101-1mg | Abbexa | 1 mg | EUR 1128 |
Norovirus GI Capsid Protein Antibody |
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| abx024102-1mg | Abbexa | 1 mg | EUR 1128 |
Norovirus GI Capsid Protein Antibody |
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| abx024103-1mg | Abbexa | 1 mg | EUR 1128 |
Norovirus GI Capsid Protein Antibody |
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| abx024099-400l | Abbexa | 400 µl | Ask for price |
Norovirus GI Capsid Protein Antibody |
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| abx024099-80l | Abbexa | 80 µl | EUR 1200 |
Norovirus GI Capsid Protein Antibody |
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| abx024100-400l | Abbexa | 400 µl | Ask for price |
Norovirus GI Capsid Protein Antibody |
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| abx024100-80l | Abbexa | 80 µl | EUR 1200 |
Norovirus GI Capsid Protein Antibody |
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| abx024101-400l | Abbexa | 400 µl | Ask for price |
Norovirus GI Capsid Protein Antibody |
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| abx024101-80l | Abbexa | 80 µl | EUR 1200 |
Norovirus GI Capsid Protein Antibody |
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| abx024102-200l | Abbexa | 200 µl | Ask for price |
Norovirus GI Capsid Protein Antibody |
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| abx024102-50l | Abbexa | 50 µl | EUR 1200 |
Norovirus GI Capsid Protein Antibody |
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| abx024103-400l | Abbexa | 400 µl | Ask for price |
Norovirus GI Capsid Protein Antibody |
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| abx024103-80l | Abbexa | 80 µl | EUR 1200 |
Outer capsid protein VP4 Antibody |
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| 20-abx319784 | Abbexa |
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Outer capsid protein VP4 Antibody |
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| 1-CSB-PA320838LA01ROH | Cusabio |
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Description: A polyclonal antibody against Outer capsid protein VP4. Recognizes Outer capsid protein VP4 from Rotavirus A. This antibody is Unconjugated. Tested in the following application: ELISA |
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Minor capsid protein VP2 Antibody |
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| 1-CSB-PA355948LA01JAK | Cusabio |
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Description: A polyclonal antibody against Minor capsid protein VP2. Recognizes Minor capsid protein VP2 from JC polyomavirus. This antibody is Unconjugated. Tested in the following application: ELISA |
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Outer capsid protein VP4 Antibody |
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| abx319784-100l | Abbexa | 100 µl | EUR 250 |
Outer capsid protein VP4 Antibody |
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| abx319784-50l | Abbexa | 50 µl | EUR 162.5 |
Norovirus GII Capsid Protein Antibody |
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| abx024104-1mg | Abbexa | 1 mg | EUR 1128 |
Norovirus GII Capsid Protein Antibody |
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| abx024105-1mg | Abbexa | 1 mg | EUR 1128 |
Norovirus GII Capsid Protein Antibody |
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| abx024106-1mg | Abbexa | 1 mg | EUR 1128 |
Norovirus GII Capsid Protein Antibody |
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| abx024107-1mg | Abbexa | 1 mg | EUR 1128 |
Norovirus GII Capsid Protein Antibody |
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| abx024108-1mg | Abbexa | 1 mg | EUR 1128 |
Rubella Virus Capsid Protein Antibody |
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| abx022208-1mg | Abbexa | 1 mg | EUR 610.8 |
Rubella Virus Capsid Protein Antibody |
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| GWB-751C39 | GenWay Biotech | 0.2 mg | Ask for price |
Norovirus GII Capsid Protein Antibody |
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| abx024104-400l | Abbexa | 400 µl | Ask for price |
Norovirus GII Capsid Protein Antibody |
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| abx024104-80l | Abbexa | 80 µl | EUR 1200 |
Norovirus GII Capsid Protein Antibody |
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| abx024105-400l | Abbexa | 400 µl | Ask for price |
Norovirus GII Capsid Protein Antibody |
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| abx024105-80l | Abbexa | 80 µl | EUR 1200 |
Norovirus GII Capsid Protein Antibody |
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| abx024106-400l | Abbexa | 400 µl | Ask for price |
Norovirus GII Capsid Protein Antibody |
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| abx024106-80l | Abbexa | 80 µl | EUR 1200 |
Norovirus GII Capsid Protein Antibody |
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| abx024107-400l | Abbexa | 400 µl | Ask for price |
Norovirus GII Capsid Protein Antibody |
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| abx024107-80l | Abbexa | 80 µl | EUR 1200 |
Norovirus GII Capsid Protein Antibody |
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| abx024108-400l | Abbexa | 400 µl | Ask for price |
Norovirus GII Capsid Protein Antibody |
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| abx024108-80l | Abbexa | 80 µl | EUR 1200 |
Rubella Virus Capsid Protein Antibody |
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| abx022208-400l | Abbexa | 400 µl | Ask for price |
Rubella Virus Capsid Protein Antibody |
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| abx022208-80l | Abbexa | 80 µl | EUR 550 |
Capsid protein VP1 Antibody (Biotin) |
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| 20-abx317826 | Abbexa |
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Capsid protein VP1 Antibody (Biotin) |
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| abx317826-100g | Abbexa | 100 µg | EUR 362.5 |
Capsid protein VP1 Antibody (Biotin) |
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| abx317826-20g | Abbexa | 20 µg | EUR 162.5 |
Capsid protein VP1 Antibody (Biotin) |
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| abx317826-50g | Abbexa | 50 µg | EUR 250 |
Major Capsid Protein L1 (L1) Antibody |
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| 20-abx317807 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody |
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| 20-abx317811 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody |
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| 20-abx317815 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody |
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| abx317811-100g | Abbexa | 100 µg | EUR 362.5 |
Minor Capsid Protein L2 (L2) Antibody |
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| abx317811-20g | Abbexa | 20 µg | EUR 162.5 |
Minor Capsid Protein L2 (L2) Antibody |
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| abx317811-50g | Abbexa | 50 µg | EUR 250 |
Minor Capsid Protein L2 (L2) Antibody |
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| abx317815-100g | Abbexa | 100 µg | EUR 362.5 |
Minor Capsid Protein L2 (L2) Antibody |
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| abx317815-20g | Abbexa | 20 µg | EUR 162.5 |
Minor Capsid Protein L2 (L2) Antibody |
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| abx317815-50g | Abbexa | 50 µg | EUR 250 |
OASA04290-100UG - CAPSID Protein Antibody |
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| OASA04290-100UG | Aviva Systems Biology | 0.1mg | EUR 309 |
Major capsid protein L1 antibody (HRP) |
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| 60R-2281 | Fitzgerald | 100 ug | EUR 302 |
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Description: Rabbit polyclonal Major capsid protein L1 antibody (HRP) |
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Capsid Protein VP2 Polyclonal Antibody |
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| A57197 | EpiGentek |
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Major capsid protein L1 antibody (FITC) |
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| 60R-2282 | Fitzgerald | 100 ug | EUR 302 |
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Description: Rabbit polyclonal Major capsid protein L1 antibody (FITC) |
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HPV18 Major capsid protein L1 Antibody |
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| 20-abx110595 | Abbexa |
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HIV-1 (Capsid protein p24), Antibody |
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| GWB-89F8F0 | GenWay Biotech | 0.2 mg | Ask for price |
HIV-2 Capsid Protein p24, Antibody |
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| GWB-6FC62E | GenWay Biotech | 0.1 mg | Ask for price |
Intermediate capsid protein VP6 Antibody |
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| 1-CSB-PA321618LA01PGK | Cusabio |
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Description: A polyclonal antibody against Intermediate capsid protein VP6. Recognizes Intermediate capsid protein VP6 from Rotavirus A. This antibody is Unconjugated. Tested in the following application: ELISA |
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Intermediate capsid protein VP6 Antibody |
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| 1-CSB-PA541481LA01ROG | Cusabio |
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Description: A polyclonal antibody against Intermediate capsid protein VP6. Recognizes Intermediate capsid protein VP6 from Rotavirus A. This antibody is Unconjugated. Tested in the following application: ELISA |
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Intermediate capsid protein VP6 Antibody |
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| 1-CSB-PA542165LA01ROH | Cusabio |
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Description: A polyclonal antibody against Intermediate capsid protein VP6. Recognizes Intermediate capsid protein VP6 from Rotavirus A. This antibody is Unconjugated. Tested in the following application: ELISA |
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Major capsid protein L1 antibody (biotin) |
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| 60R-2283 | Fitzgerald | 100 ug | EUR 302 |
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Description: Rabbit polyclonal Major capsid protein L1 antibody (biotin) |
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Outer capsid protein VP4 Antibody (HRP) |
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| 20-abx319785 | Abbexa |
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Outer capsid protein VP4 Antibody (HRP) |
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| abx319785-100l | Abbexa | 100 µl | EUR 250 |
Outer capsid protein VP4 Antibody (HRP) |
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| abx319785-50l | Abbexa | 50 µl | EUR 162.5 |
Outer capsid protein VP4 Antibody (FITC) |
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| 20-abx319786 | Abbexa |
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Outer capsid protein VP4 Antibody (FITC) |
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| abx319786-100l | Abbexa | 100 µl | EUR 250 |
Outer capsid protein VP4 Antibody (FITC) |
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| abx319786-50l | Abbexa | 50 µl | EUR 162.5 |
RHDV major capsid protein VP60 Antibody |
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| E300729 | EnoGene | 200ul | EUR 275 |
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Description: Available in various conjugation types. |
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Major Capsid Protein L1 (L1) Antibody (HRP) |
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| 20-abx317808 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody (HRP) |
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| 20-abx317812 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody (HRP) |
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| 20-abx317816 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody (HRP) |
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| abx317812-100g | Abbexa | 100 µg | EUR 362.5 |
Minor Capsid Protein L2 (L2) Antibody (HRP) |
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| abx317812-20g | Abbexa | 20 µg | EUR 162.5 |
Minor Capsid Protein L2 (L2) Antibody (HRP) |
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| abx317812-50g | Abbexa | 50 µg | EUR 250 |
Minor Capsid Protein L2 (L2) Antibody (HRP) |
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| abx317816-100g | Abbexa | 100 µg | EUR 362.5 |
Minor Capsid Protein L2 (L2) Antibody (HRP) |
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| abx317816-20g | Abbexa | 20 µg | EUR 162.5 |
Minor Capsid Protein L2 (L2) Antibody (HRP) |
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| abx317816-50g | Abbexa | 50 µg | EUR 250 |
Outer capsid protein VP4 Antibody (Biotin) |
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| 20-abx319787 | Abbexa |
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Outer capsid protein VP4 Antibody (Biotin) |
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| abx319787-100l | Abbexa | 100 µl | EUR 250 |
Outer capsid protein VP4 Antibody (Biotin) |
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| abx319787-50l | Abbexa | 50 µl | EUR 162.5 |
Major Capsid Protein L1 (L1) Antibody (FITC) |
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| 20-abx317809 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody (FITC) |
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| 20-abx317813 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody (FITC) |
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| 20-abx317817 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody (FITC) |
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| abx317813-100g | Abbexa | 100 µg | EUR 362.5 |
Minor Capsid Protein L2 (L2) Antibody (FITC) |
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| abx317813-20g | Abbexa | 20 µg | EUR 162.5 |
Minor Capsid Protein L2 (L2) Antibody (FITC) |
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| abx317813-50g | Abbexa | 50 µg | EUR 250 |
Minor Capsid Protein L2 (L2) Antibody (FITC) |
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| abx317817-100g | Abbexa | 100 µg | EUR 362.5 |
Minor Capsid Protein L2 (L2) Antibody (FITC) |
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| abx317817-20g | Abbexa | 20 µg | EUR 162.5 |
Minor Capsid Protein L2 (L2) Antibody (FITC) |
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| abx317817-50g | Abbexa | 50 µg | EUR 250 |
Capsid protein VP1 Antibody, HRP conjugated |
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| 1-CSB-PA362102LB01HPM | Cusabio |
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Description: A polyclonal antibody against Capsid protein VP1. Recognizes Capsid protein VP1 from Human parvovirus B19. This antibody is HRP conjugated. Tested in the following application: ELISA |
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Major Capsid Protein L1 (L1) Antibody (Biotin) |
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| 20-abx317810 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody (Biotin) |
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| 20-abx317814 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody (Biotin) |
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| 20-abx317818 | Abbexa |
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HPV18 Major capsid protein L1 Antibody (HRP) |
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| 20-abx109154 | Abbexa |
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Minor Capsid Protein L2 (L2) Antibody (Biotin) |
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| abx317814-100g | Abbexa | 100 µg | EUR 362.5 |
Minor Capsid Protein L2 (L2) Antibody (Biotin) |
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| abx317814-20g | Abbexa | 20 µg | EUR 162.5 |
Minor Capsid Protein L2 (L2) Antibody (Biotin) |
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| abx317814-50g | Abbexa | 50 µg | EUR 250 |
Minor Capsid Protein L2 (L2) Antibody (Biotin) |
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| abx317818-100g | Abbexa | 100 µg | EUR 362.5 |
Minor Capsid Protein L2 (L2) Antibody (Biotin) |
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| abx317818-20g | Abbexa | 20 µg | EUR 162.5 |
Minor Capsid Protein L2 (L2) Antibody (Biotin) |
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| abx317818-50g | Abbexa | 50 µg | EUR 250 |
Capsid protein VP1 Antibody, FITC conjugated |
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| 1-CSB-PA362102LC01HPM | Cusabio |
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Description: A polyclonal antibody against Capsid protein VP1. Recognizes Capsid protein VP1 from Human parvovirus B19. This antibody is FITC conjugated. Tested in the following application: ELISA |
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Escherichia Phage Qbeta Capsid Protein Antibody |
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| abx345659-100l | Abbexa | 100 µl | EUR 350 |
Escherichia Phage Qbeta Capsid Protein Antibody |
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| abx345659-50l | Abbexa | 50 µl | EUR 250 |
HPV18 Major capsid protein L1 Antibody (FITC) |
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| 20-abx107736 | Abbexa |
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Intermediate capsid protein VP6 Antibody (HRP) |
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| 20-abx319789 | Abbexa |
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Intermediate capsid protein VP6 Antibody (HRP) |
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| 20-abx319793 | Abbexa |
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Minor Capsid Protein VP2 Polyclonal Antibody |
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| A55206 | EpiGentek |
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Outer Capsid Protein VP4 Polyclonal Antibody |
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| A57461 | EpiGentek |
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Intermediate Capsid Protein VP6 (VP6) Antibody |
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| abx319788-100l | Abbexa | 100 µl | EUR 250 |
Intermediate Capsid Protein VP6 (VP6) Antibody |
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| abx319788-50l | Abbexa | 50 µl | EUR 162.5 |
Intermediate capsid protein VP6 Antibody (HRP) |
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| abx319789-100l | Abbexa | 100 µl | EUR 250 |
Intermediate capsid protein VP6 Antibody (HRP) |
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| abx319789-50l | Abbexa | 50 µl | EUR 162.5 |
Intermediate Capsid Protein VP6 (VP6) Antibody |
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| abx319792-100l | Abbexa | 100 µl | EUR 250 |
Intermediate Capsid Protein VP6 (VP6) Antibody |
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| abx319792-50l | Abbexa | 50 µl | EUR 162.5 |
Intermediate capsid protein VP6 Antibody (HRP) |
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| abx319793-100l | Abbexa | 100 µl | EUR 250 |
Intermediate capsid protein VP6 Antibody (HRP) |
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| abx319793-50l | Abbexa | 50 µl | EUR 162.5 |
Intermediate capsid protein VP6 Antibody (FITC) |
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| 20-abx319790 | Abbexa |
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Intermediate capsid protein VP6 Antibody (FITC) |
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| 20-abx319794 | Abbexa |
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Capsid protein VP1 Antibody, Biotin conjugated |
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| 1-CSB-PA362102LD01HPM | Cusabio |
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Description: A polyclonal antibody against Capsid protein VP1. Recognizes Capsid protein VP1 from Human parvovirus B19. This antibody is Biotin conjugated. Tested in the following application: ELISA |
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Intermediate capsid protein VP6 Antibody (FITC) |
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| abx319790-100l | Abbexa | 100 µl | EUR 250 |
Intermediate capsid protein VP6 Antibody (FITC) |
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| abx319790-50l | Abbexa | 50 µl | EUR 162.5 |
Intermediate capsid protein VP6 Antibody (FITC) |
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| abx319794-100l | Abbexa | 100 µl | EUR 250 |
Intermediate capsid protein VP6 Antibody (FITC) |
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| abx319794-50l | Abbexa | 50 µl | EUR 162.5 |
HPV18 Major capsid protein L1 Antibody (Biotin) |
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| 20-abx106323 | Abbexa |
|
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Intermediate capsid protein VP6 Antibody (Biotin) |
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| 20-abx319791 | Abbexa |
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Intermediate capsid protein VP6 Antibody (Biotin) |
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| 20-abx319795 | Abbexa |
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Intermediate capsid protein VP6 Antibody (Biotin) |
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| abx319791-100l | Abbexa | 100 µl | EUR 250 |
Intermediate capsid protein VP6 Antibody (Biotin) |
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| abx319791-50l | Abbexa | 50 µl | EUR 162.5 |
Intermediate capsid protein VP6 Antibody (Biotin) |
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| abx319795-100l | Abbexa | 100 µl | EUR 250 |
Intermediate capsid protein VP6 Antibody (Biotin) |
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| abx319795-50l | Abbexa | 50 µl | EUR 162.5 |
Intermediate Capsid Protein VP6 Polyclonal Antibody |
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| A57101 | EpiGentek |
|
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Intermediate Capsid Protein VP6 Polyclonal Antibody |
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| A55018 | EpiGentek |
|
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When β-cells had been cultured on REP, Erk and the phosphatidylinositol 3-kinase (PI3-kinase) downstream effector, Akt was stimulated. Treatment with the Erk pathway inhibitor and PI3-kinase inhibitor decreased REP-induced β-cell adhesion and proliferation, and controlled REP-induced cell cycle proteins. Additionally, REP elevated the mRNA and protein ranges of insulin and its transcription issue, PDX-1, and insulin secretion. Our outcomes reveal that the up-regulation of the PI3K/Akt and Erk signaling pathways and the regulation of cell cycle proteins by REP may function efficient methods for enhancing pancreatic β-cell adhesion and proliferation.
Phosphorylation inhibition of protein-tyrosine phosphatase 1B tyrosine-152 induces bone regeneration coupled with angiogenesis for bone tissue engineering