Ras undergoes interconversion between the energetic GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the actions of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide trade elements (SOS). Oncogenic Ras mutations might have an effect on the GTPase cycle and impair Ras capabilities. Additionally, Src-induced Ok-Ras Y32/64 twin phosphorylation has been reported to disrupt GTPase cycle and hinder Ras downstream signaling. However, the underlying mechanisms stay unclear. To handle this, we carried out molecular dynamics simulations (~30 μs in complete) on unphosphorylated and phosphorylated Ok-Ras4B in GTP- and GDP-bound states, and on their complexes with GTPase cycle regulators (GAP and SOS) and the effector protein Raf.
We discovered that Ok-Ras4B twin phosphorylation primarily alters the conformation at the nucleotide binding website and creates dysfunction at the catalytic website, leading to the enlargement of GDP binding pocket and the retard of Ras-GTP intrinsic hydrolysis. We noticed phosphorylation-induced shift in the distribution of Ras-GTP inactive-active sub-states and acknowledged potential druggable pockets in the phosphorylated Ras-GTP. Moreover, decreased catalytic competence or sign supply skills because of diminished binding affinities and/or distorted catalytic conformations of GAP, SOS and Raf have been noticed.
In addition, the allosteric pathway from Ras/Raf interface to the distal Raf L4 loop was compromised by Ras phosphorylation. These outcomes reveal the mechanisms by which phosphorylation influences the intrinsic or GAP/SOS catalyzed transformations between GTP- and GDP-bound states of Ras and its sign transduction to Raf. Our findings challenge Ras phosphorylation as a goal for most cancers drug discovery.
Uncovering the Effect of pS202/pT205/pS208 Triple Phosphorylations on the Conformational Features of the Key Fragment G192-T212 of Tau Protein
Microtubule-associated protein tau is abnormally phosphorylated and kinds the aggregates of paired helical filaments in Alzheimer’s illness (AD) and different tauopathies. So far, the relationship and mechanism between the irregular phosphorylation of tau and fibril formation remains to be unclear. Therefore, learning the effect of phosphorylation on the construction of tau protein is useful to elucidate the pathogenic mechanism of tauopathies. It has been proven that pS202/pT205/pS208 triple phosphorylations situated in the proline-rich area can promote tau aggregation. In this work, the effect of triple phosphorylations on tau construction was investigated by molecular dynamics simulations mixed with a number of analytical strategies of trajectories.
The outcomes confirmed that the conformational range of G192-T212 fragments decreased after phosphorylation in contrast with that of the wild-type. Moreover, the dynamic community and hydrogen bond analyses confirmed that the addition of pS208 phosphorylation can destroy the key hydrogen bonds and the community construction fashioned centered on pT205 at the C-terminal of the pS202/pT205 double phosphorylated peptide and then destroy the flip construction fashioned in the area of G207-R211. The destruction of this flip construction is taken into account to be the most important purpose for the aggregation of pS202/pT205/pS208 triple phosphorylations.
Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin ββ
Alzheimer’s illness (AD) is a neurodegenerative dysfunction characterised by irregular deposition of ββ-amyloid (Aββ) peptides. Aββ is a cleavage product of the amyloid precursor protein (APP), and aberrant posttranslational modifications of APP can alter APP processing and improve Aββ technology. In the AD mind, seven totally different residues, together with Ser-675 (APP695 numbering) in the APP cytoplasmic area has been discovered to be phosphorylated. Here, we present that expression of a phosphomimetic variant of Ser-675 in APP (APP-S675E), in human neuroblastoma SK-N-AS cells, reduces secretion of the soluble APP ectodomain (sAPPα), regardless that the complete plasma membrane degree of APP was unchanged in contrast with APP ranges in cells expressing APPwt or APP-S675A.
Moreover, the degree of an alternate bigger C-terminal fragment (CTF) elevated in the APP-S675E cells, whereas the CTF kind that was most ample in cells expressing APPwt or APP-S675A decreased in the APP-S675E cells. Upon siRNA-mediated knockdown of the astacin metalloprotease meprin ββ, the ranges of the various CTF decreased and the CTF ratio was restored again to APPwt ranges. Our findings counsel that APP-Ser-675 phosphorylation alters the steadiness of APP processing, rising meprin ββ-mediated and lowering α-secretase-mediated processing of APP at the plasma membrane.
As meprin ββ cleavage of APP has been proven to end in formation of extremely aggregation-prone, truncated Aββ2-40/42 peptides, enhanced APP processing by this enzyme might contribute to AD pathology. We suggest that it could be of curiosity to make clear in future research how APP-Ser-675 phosphorylation promotes meprin ββ-mediated APP cleavage. We utilized SILAF to quantify the mitochondrial phosphoproteome of an early-stage leucine-rich PPR motif-containing protein (LRPPRC)-knockdown fly mannequin of mitochondrial illness that just about completely impacts protein ranges of the oxidative phosphorylation (OXPHOS) system. While the mitochondrial compartment was hypo-phosphorylated, two conserved phospho-sites on OXPHOS subunits NDUFB10 and NDUFA4 have been considerably upregulated upon impaired OXPHOS perform.
IL1F6 Protein Vector (Human) (pPB-N-His) |
PV053374 |
ABM |
500 ng |
EUR 577.2 |
IL1F6 Protein Vector (Human) (pPM-C-His) |
PV053376 |
ABM |
500 ng |
EUR 577.2 |
Recombinant Human IL1F6/IL36A Protein (His Tag) |
PKSH031509-20ug |
Elabscience Biotech |
20ug |
EUR 508 |
|
Description: Human |
Recombinant Human IL1F6/ IL36 Protein, GST, E.coli-1mg |
QP8208-ec-1mg |
EnQuireBio |
1mg |
EUR 1958.4 |
Recombinant Human IL1F6/ IL36 Protein, GST, E.coli-10ug |
QP8208-ec-10ug |
EnQuireBio |
10ug |
EUR 240 |
Recombinant Human IL1F6/ IL36 Protein, GST, E.coli-50ug |
QP8208-ec-50ug |
EnQuireBio |
50ug |
EUR 315.6 |
Recombinant Human IL1F6/ IL36 Protein, GST, E.coli-100ug |
QP8208-ec-100ug |
EnQuireBio |
100ug |
EUR 489.6 |
Recombinant Human IL1F6/ IL36 Protein, GST, E.coli-200ug |
QP8208-ec-200ug |
EnQuireBio |
200ug |
EUR 760.8 |
Recombinant Human IL1F6/ IL36 Protein, GST, E.coli-500ug |
QP8208-ec-500ug |
EnQuireBio |
500ug |
EUR 1272 |
Recombinant Human IL1F6/ IL36 Protein, Untagged, E.coli-2ug |
QP10330-ec-2ug |
EnQuireBio |
2ug |
EUR 184.8 |
Recombinant Human IL1F6/ IL36 Protein, Untagged, E.coli-10ug |
QP10330-ec-10ug |
EnQuireBio |
10ug |
EUR 348 |
Recombinant Human IL1F6/ IL36 Protein, Untagged, E.coli-100ug |
QP10330-ec-100ug |
EnQuireBio |
100ug |
EUR 2394 |
Recombinant Human IL1F6/ IL36 Protein, Untagged, E.coli-250ug |
QP10330-ec-250ug |
EnQuireBio |
250ug |
EUR 4243.2 |
Recombinant Mouse IL1F6/IL36A Protein |
PKSM041092-10ug |
Elabscience Biotech |
10ug |
EUR 129 |
|
Description: Mouse |
Recombinant Mouse IL1F6/IL36A Protein |
PKSM041092-50ug |
Elabscience Biotech |
50ug |
EUR 375 |
|
Description: Mouse |
IL1F6 Protein Vector (Rat) (pPM-C-HA) |
PV274424 |
ABM |
500 ng |
EUR 723.6 |
IL1F6 Protein Vector (Rat) (pPB-C-His) |
PV274422 |
ABM |
500 ng |
EUR 723.6 |
IL1F6 Protein Vector (Rat) (pPB-N-His) |
PV274423 |
ABM |
500 ng |
EUR 723.6 |
IL1F6 Protein Vector (Rat) (pPM-C-His) |
PV274425 |
ABM |
500 ng |
EUR 723.6 |
IL1F6 Protein Vector (Mouse) (pPM-C-HA) |
PV191364 |
ABM |
500 ng |
EUR 723.6 |
IL1F6 Protein Vector (Mouse) (pPB-C-His) |
PV191362 |
ABM |
500 ng |
EUR 723.6 |
IL1F6 Protein Vector (Mouse) (pPB-N-His) |
PV191363 |
ABM |
500 ng |
EUR 723.6 |
IL1F6 Protein Vector (Mouse) (pPM-C-His) |
PV191365 |
ABM |
500 ng |
EUR 723.6 |
IL1F6 ORF Vector (Human) (pORF) |
ORF013344 |
ABM |
1.0 ug DNA |
EUR 114 |
Recombinant Mouse IL1F6/ IL36 Protein, Untagged, E.coli-2ug |
QP10465-ec-2ug |
EnQuireBio |
2ug |
EUR 184.8 |
Recombinant Mouse IL1F6/ IL36 Protein, Untagged, E.coli-10ug |
QP10465-ec-10ug |
EnQuireBio |
10ug |
EUR 348 |
Recombinant Mouse IL1F6/ IL36 Protein, Untagged, E.coli-100ug |
QP10465-ec-100ug |
EnQuireBio |
100ug |
EUR 2394 |
Recombinant Mouse IL1F6/ IL36 Protein, Untagged, E.coli-250ug |
QP10465-ec-250ug |
EnQuireBio |
250ug |
EUR 4243.2 |
IL1F6 Antibody |
E311424 |
EnoGene |
200ul |
EUR 275 |
Description: Available in various conjugation types. |
IL1F6 Antibody |
44817-100ul |
SAB |
100ul |
EUR 302.4 |
IL1F6 Antibody |
44817-50ul |
SAB |
50ul |
EUR 224.4 |
IL1F6 sgRNA CRISPR Lentivector set (Human) |
K1074101 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
Human Interleukin-36 alpha(IL1F6) ELISA kit |
CSB-EL011617HU-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin-36 alpha (IL1F6) in samples from serum, plasma, tissue homogenates, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Interleukin-36 alpha(IL1F6) ELISA kit |
1-CSB-EL011617HU |
Cusabio |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin-36 alpha(IL1F6) in samples from serum, plasma, tissue homogenates, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Interleukin-36 alpha (IL1F6) ELISA Kit |
AE57345HU-48Tests |
Abebio |
48 Tests |
EUR 325 |
|
Description: Human (Homo sapiens) |
Human Interleukin-36 alpha (IL1F6) ELISA Kit |
AE57345HU-96Tests |
Abebio |
96 Tests |
EUR 610 |
|
Description: Human (Homo sapiens) |
Human Interleukin-36 alpha (IL1F6) ELISA Kit |
RK10998 |
Abclonal |
96T |
EUR 280 |
Human Interleukin-36 alpha (IL1F6) ELISA kit |
SL3785Hu |
Sunlong |
96 Tests |
EUR 468 |
|
IL1F6 sgRNA CRISPR Lentivector (Human) (Target 1) |
K1074102 |
ABM |
1.0 ug DNA |
EUR 184.8 |
IL1F6 sgRNA CRISPR Lentivector (Human) (Target 2) |
K1074103 |
ABM |
1.0 ug DNA |
EUR 184.8 |
IL1F6 sgRNA CRISPR Lentivector (Human) (Target 3) |
K1074104 |
ABM |
1.0 ug DNA |
EUR 184.8 |
IL1F6 Blocking Peptide |
DF2524-BP |
Affbiotech |
1mg |
EUR 234 |
Human Interleukin-36 Alpha, IL1F6 GENLISA ELISA |
KBH5524 |
Krishgen |
1 x 96 wells |
EUR 286 |
IL1F6 Conjugated Antibody |
C44817 |
SAB |
100ul |
EUR 476.4 |
Il1f6 (untagged) - Mouse interleukin 1 family, member 6 (Il1f6), (10ug) |
MC209979 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Il1f6 (GFP-tagged) - Mouse interleukin 1 family member 6 (Il1f6), (10ug) |
MG225118 |
Origene Technologies GmbH |
10 µg |
Ask for price |
IL1F6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
LV815007 |
ABM |
1.0 ug DNA |
EUR 540 |
IL1F6 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC) |
LV815011 |
ABM |
1.0 ug DNA |
EUR 540 |
IL1F6 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a) |
LV815012 |
ABM |
1.0 ug DNA |
EUR 540 |
IL1F6 Over-expression Lysate Product |
GWB-182A36 |
GenWay Biotech |
0.1 mg |
Ask for price |
|
Il1f6 ORF Vector (Rat) (pORF) |
ORF068606 |
ABM |
1.0 ug DNA |
EUR 607.2 |
Il1f6 ORF Vector (Mouse) (pORF) |
ORF047841 |
ABM |
1.0 ug DNA |
EUR 607.2 |
IL1F6 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human) |
K1074105 |
ABM |
3 x 1.0 ug |
EUR 451.2 |
Lenti ORF clone of Il1f6 (mGFP-tagged) - Mouse interleukin 1 family, member 6 (Il1f6) |
MR225118L4 |
Origene Technologies GmbH |
10 µg |
Ask for price |
IL36A (untagged)-Human interleukin 1 family, member 6 (epsilon) (IL1F6) |
SC304107 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Human IL1F10 Protein, His Tag |
E40KMPH1237 |
EnoGene |
20ug |
EUR 495 |
Lenti ORF clone of Il1f6 (Myc-DDK-tagged) - Mouse interleukin 1 family, member 6 (Il1f6) |
MR225118L3 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Human IL1F10 Protein Lysate 20ug |
IHUIL1F10PLLY20UG |
Innovative research |
each |
EUR 213 |
|
Description: Human IL1F10 Protein Lysate 20ug |
IL36A (GFP-tagged) - Human interleukin 1 family, member 6 (epsilon) (IL1F6) |
RG219328 |
Origene Technologies GmbH |
10 µg |
Ask for price |
IL1F6 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1) |
K1074106 |
ABM |
1.0 ug DNA |
EUR 200.4 |
IL1F6 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2) |
K1074107 |
ABM |
1.0 ug DNA |
EUR 200.4 |
IL1F6 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3) |
K1074108 |
ABM |
1.0 ug DNA |
EUR 200.4 |
Recombinant Human IL-1F10 Protein |
E40KMP1761 |
EnoGene |
20ug |
EUR 495 |
Recombinant Human IL-1F10 Protein |
RP01084 |
Abclonal |
10 μg |
EUR 1137.5 |
|
IL1F6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA) |
LV815008 |
ABM |
1.0 ug DNA |
EUR 540 |
Il1f6 sgRNA CRISPR Lentivector set (Rat) |
K6578501 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
IL1F6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro) |
LV815009 |
ABM |
1.0 ug DNA |
EUR 609.6 |
IL1F6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro) |
LV815010 |
ABM |
1.0 ug DNA |
EUR 609.6 |
Recombinant Human IL1F10/IL-38 Protein |
PKSH033637-100ug |
Elabscience Biotech |
100ug |
EUR 739 |
|
Description: Human |
Recombinant Human IL1F10/IL-38 Protein |
PKSH033637-20ug |
Elabscience Biotech |
20ug |
EUR 249 |
|
Description: Human |
Il1f6 sgRNA CRISPR Lentivector set (Mouse) |
K3933201 |
ABM |
3 x 1.0 ug |
EUR 406.8 |
IL1F10 Protein Vector (Human) (pPM-C-HA) |
PV053371 |
ABM |
500 ng |
EUR 577.2 |
IL1F10 Protein Vector (Human) (pPB-C-His) |
PV053369 |
ABM |
500 ng |
EUR 577.2 |
IL1F10 Protein Vector (Human) (pPB-N-His) |
PV053370 |
ABM |
500 ng |
EUR 577.2 |
IL1F10 Protein Vector (Human) (pPM-C-His) |
PV053372 |
ABM |
500 ng |
EUR 577.2 |
IL1F6 3'UTR GFP Stable Cell Line |
TU061019 |
ABM |
1.0 ml |
EUR 2799.6 |
Il1f6 3'UTR GFP Stable Cell Line |
TU160040 |
ABM |
1.0 ml |
Ask for price |
Il1f6 3'UTR GFP Stable Cell Line |
TU256220 |
ABM |
1.0 ml |
Ask for price |
IL36A (Myc-DDK-tagged)-Human interleukin 1 family, member 6 (epsilon) (IL1F6) |
RC219328 |
Origene Technologies GmbH |
10 µg |
Ask for price |
Lenti ORF particles, Il1f6 (GFP-tagged) - Mouse interleukin 1 family, member 6 (Il1f6), 200ul, >10^7 TU/mL |
MR225118L4V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Human IL-37 / IL-1F7 Protein, His Tag |
ILB-H51H5 |
ACROBIOSYSTEMS |
500ug |
EUR 267.5 |
|
Description: Human IL-37, His Tag (ILB-H51H5) is expressed from E. coli cells. It contains AA Lys 27 - Asp 192 (Accession # Q9NZH6-2). |
Recombinant Human IL36G/IL1F9 Protein |
PKSH031852-50ug |
Elabscience Biotech |
50ug |
EUR 564 |
|
Description: Human |
Recombinant Human IL1F10/IL-38 Protein (His Tag) |
PKSH031856-100ug |
Elabscience Biotech |
100ug |
EUR 487 |
|
Description: Human |
Recombinant Human IL1F5/IL36RN Protein |
PKSH031850-100ug |
Elabscience Biotech |
100ug |
EUR 739 |
|
Description: Human |
Recombinant Human IL1F5/IL36RN Protein |
PKSH031850-20ug |
Elabscience Biotech |
20ug |
EUR 249 |
|
Description: Human |
Human IL-37b / IL-1F7b Protein, His Tag |
ILB-H5141 |
ACROBIOSYSTEMS |
500ug |
EUR 267.5 |
|
Description: Human IL-37b, His Tag (ILB-H5141) is expressed from E. coli cells. It contains AA Val 46 - Asp 218 (Accession # AAH20637.1). |
Il1f6 3'UTR Luciferase Stable Cell Line |
TU110040 |
ABM |
1.0 ml |
Ask for price |
IL1F6 3'UTR Luciferase Stable Cell Line |
TU011019 |
ABM |
1.0 ml |
EUR 2799.6 |
Il1f6 3'UTR Luciferase Stable Cell Line |
TU206220 |
ABM |
1.0 ml |
Ask for price |
Lenti ORF particles, Il1f6 (Myc-DDK-tagged) - Mouse interleukin 1 family, member 6 (Il1f6), 200ul, >10^7 TU/mL |
MR225118L3V |
Origene Technologies GmbH |
200 µl |
Ask for price |
Recombinant Human IL36G/IL1F9 Protein (aa 18-169) |
PKSH031851-20ug |
Elabscience Biotech |
20ug |
EUR 363 |
|
Description: Human |
IL1F5 Protein Vector (Human) (pPM-C-HA) |
PV021287 |
ABM |
500 ng |
EUR 394.8 |
IL1F7 Protein Vector (Human) (pPM-C-HA) |
PV021291 |
ABM |
500 ng |
EUR 394.8 |
IL1F9 Protein Vector (Human) (pPM-C-HA) |
PV053379 |
ABM |
500 ng |
EUR 577.2 |
Mouse Interleukin-36 alpha(IL1F6) ELISA kit |
CSB-EL011617MO-24T |
Cusabio |
1 plate of 24 wells |
EUR 198 |
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin-36 alpha (IL1F6) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Mouse Interleukin-36 alpha(IL1F6) ELISA kit |
1-CSB-EL011617MO |
Cusabio |
-
Ask for price
-
Ask for price
-
Ask for price
|
- 1 plate of 96 wells
- 10 plates of 96 wells each
- 5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Mouse Interleukin-36 alpha(IL1F6) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Il1f6 sgRNA CRISPR Lentivector (Rat) (Target 1) |
K6578502 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Il1f6 sgRNA CRISPR Lentivector (Rat) (Target 2) |
K6578503 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Il1f6 sgRNA CRISPR Lentivector (Rat) (Target 3) |
K6578504 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Human IL-37 (IL-1F7) Recombinant Protein |
100-161 |
ReliaTech |
25 µg |
EUR 196.35 |
Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-37 (IL-1F7), which acts as a modulator of the immune response. Reduction of IL-37 synthesis in PBMCs leads to increased production of proinflammatory cytokines including IL-1 alpha, IL-1 beta, IL-6 and TNF- alpha. The role of IL-37 as an inhibitor of the innate inflammatory response is also corroborated by the observation that it is highly expressed in synovial tissue from patients with rheumatoid arthritis. Full length IL-37 resides primarily in the cytoplasm, but after activation through cleavage by CASP1, it can translocate to the nucleus where it exerts its activity by direct interaction with SMAD3. Recombinant Human IL-37 is a 19.4 kDa protein consisting of 174 amino acids, corresponding to the mature activated form of IL-37. |
Human IL-37 (IL-1F7) Recombinant Protein |
100-161S |
ReliaTech |
5 µg |
EUR 92.4 |
Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-37 (IL-1F7), which acts as a modulator of the immune response. Reduction of IL-37 synthesis in PBMCs leads to increased production of proinflammatory cytokines including IL-1 alpha, IL-1 beta, IL-6 and TNF- alpha. The role of IL-37 as an inhibitor of the innate inflammatory response is also corroborated by the observation that it is highly expressed in synovial tissue from patients with rheumatoid arthritis. Full length IL-37 resides primarily in the cytoplasm, but after activation through cleavage by CASP1, it can translocate to the nucleus where it exerts its activity by direct interaction with SMAD3. Recombinant Human IL-37 is a 19.4 kDa protein consisting of 174 amino acids, corresponding to the mature activated form of IL-37. |
Recombinant Human IL-37/IL-1F7 Protein |
RP02509 |
Abclonal |
50μg |
EUR 520 |
|
IL1F5 Protein Vector (Human) (pPB-C-His) |
PV021285 |
ABM |
500 ng |
EUR 394.8 |
IL1F5 Protein Vector (Human) (pPB-N-His) |
PV021286 |
ABM |
500 ng |
EUR 394.8 |
IL1F5 Protein Vector (Human) (pPM-C-His) |
PV021288 |
ABM |
500 ng |
EUR 394.8 |
IL1F7 Protein Vector (Human) (pPB-C-His) |
PV021289 |
ABM |
500 ng |
EUR 394.8 |
IL1F7 Protein Vector (Human) (pPB-N-His) |
PV021290 |
ABM |
500 ng |
EUR 394.8 |
IL1F7 Protein Vector (Human) (pPM-C-His) |
PV021292 |
ABM |
500 ng |
EUR 394.8 |
IL1F9 Protein Vector (Human) (pPB-C-His) |
PV053377 |
ABM |
500 ng |
EUR 577.2 |
IL1F9 Protein Vector (Human) (pPB-N-His) |
PV053378 |
ABM |
500 ng |
EUR 577.2 |
IL1F9 Protein Vector (Human) (pPM-C-His) |
PV053380 |
ABM |
500 ng |
EUR 577.2 |
Il1f6 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
K3933202 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Il1f6 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
K3933203 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Il1f6 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
K3933204 |
ABM |
1.0 ug DNA |
EUR 184.8 |
Interleukin-1 Family Member 6 (IL1F6) Antibody |
20-abx215373 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
Interleukin-1 Family Member 6 (IL1F6) Antibody |
20-abx005735 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
-
Ask for price
|
- 100 ul
- 200 ul
- 20 ul
- 50 ul
|
|
Interleukin-1 Family Member 6 (IL1F6) Antibody |
abx032449-400ul |
Abbexa |
400 ul |
EUR 627.6 |
|
Interleukin-1 Family Member 6 (IL1F6) Antibody |
abx032449-80l |
Abbexa |
80 µl |
EUR 343.2 |
|
Interleukin-1 Family Member 6 (IL1F6) Antibody |
abx005735-100g |
Abbexa |
100 µg |
EUR 175 |
Interleukin-1 Family Member 6 (IL1F6) Antibody |
abx032449-400l |
Abbexa |
400 µl |
EUR 518.75 |
Interleukin-1 Family Member 6 (IL1F6) Antibody |
abx375341-96tests |
Abbexa |
96 tests |
EUR 337.5 |
Recombinant Human IL-36Ra/IL-1F5 Protein |
RP00030 |
Abclonal |
5 μg |
EUR 136.5 |
|
Recombinant Human IL-36Ra/IL-1F5 Protein |
RP00494 |
Abclonal |
10 μg |
EUR 265.2 |
Mouse Interleukin-36 alpha, IL1F6 GENLISA ELISA |
KLM2191 |
Krishgen |
1 x 96 wells |
EUR 341 |
Recombinant Human IL36G/IL1F9 Protein (Active) |
PKSH032644-100ug |
Elabscience Biotech |
100ug |
EUR 739 |
|
Description: Human |
Recombinant Human IL36G/IL1F9 Protein (Active) |
PKSH032644-20ug |
Elabscience Biotech |
20ug |
EUR 249 |
|
Description: Human |
Human Interleukin-1 Family Member 10 (IL1F10) Protein |
abx168252-100l |
Abbexa |
100 µl |
EUR 225 |
Human Interleukin-1 Family Member 10 (IL1F10) Protein |
abx168252-1ml |
Abbexa |
1 ml |
EUR 587.5 |
Human Interleukin-1 Family Member 10 (IL1F10) Protein |
abx168252-200l |
Abbexa |
200 µl |
EUR 400 |
Human Interleukin 36 Gamma / IL1F9 (IL36G) Protein |
abx067397-100g |
Abbexa |
100 µg |
EUR 600 |
Human Interleukin 36 Gamma / IL1F9 (IL36G) Protein |
abx067397-10g |
Abbexa |
10 µg |
EUR 225 |
Human Interleukin 36 Gamma / IL1F9 (IL36G) Protein |
abx067397-50g |
Abbexa |
50 µg |
EUR 412.5 |
Human IL-36 beta (IL-1F8) Recombinant Protein |
100-091 |
ReliaTech |
10 µg |
EUR 196.35 |
Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues. |
Human IL-36 beta (IL-1F8) Recombinant Protein |
100-091S |
ReliaTech |
2 µg |
EUR 92.4 |
Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues. |
Recombinant Human IL-36 beta/IL-1F8 Protein |
RP00020 |
Abclonal |
5 μg |
EUR 260 |
|
Recombinant Human IL-36 Beta (IL-1F8) Protein |
PROTQ9NZH7-2 |
BosterBio |
10ug |
EUR 380.4 |
Description: The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues. |
Recombinant Human IL36G/IL1F9 Protein (aa 18-169, His Tag) |
PKSH031853-20ug |
Elabscience Biotech |
20ug |
EUR 363 |
|
Description: Human |
Human IL-1 beta / IL-1F2 Protein, premium grade |
ILB-H4110 |
ACROBIOSYSTEMS |
20ug |
EUR 3006.7 |
|
Description: Human IL-1 beta, premium grade (ILB-H4110) is expressed from E. coli cells. It contains AA Ala 117 - Ser 269 (Accession # P01584-1). |
The ease and versatility of the technique actuates the fruit fly as an interesting mannequin in proteomic and post-translational modification research and it enlarges potential metabolic purposes primarily based on heavy amino acid diets. For the pS202/pT205/pS208 triple phosphorylated system, the G207-R211 area is a coil construction, which is extra prolonged and susceptible to aggregation. In a phrase, our outcomes reveal the mechanism that pS202/pT205/pS208 triple phosphorylations promote tau aggregation at the atomic degree, which might present helpful theoretical steering for the rational design of efficient therapeutic medication in opposition to AD and different tauopathies.