Ras undergoes interconversion between the energetic GTP-bound state and the inactive GDP-bound state. This GTPase cycle, which controls the actions of Ras, is accelerated by Ras GTPase-activating proteins (GAPs) and guanine nucleotide trade elements (SOS). Oncogenic Ras mutations might have…
Glucocorticoid receptor Thr524 phosphorylation by MINK1 induces interactions with 14-3-3 protein regulators
Glucocorticoid receptor (GR) is a ligand-dependent transcription issue that performs a central position in irritation. GR exercise can also be modulated by way of protein-protein interactions, together with binding of 14-3-Three proteins induced by GR phosphorylation. However, the particular phosphorylation…